ABSTRACT
Agricultural waste has always been a global problem that causes environmental pollution, and thanks to the efforts of scientists, this agricultural waste has become not a neglected product, but rather a source of many effective chemical compounds that have industrial, pharmaceutical and food applications. Viral disease therapy has attracted a great deal of scientific interest worldwide. Therefore, the pace of research is increasing for effective and safe treatment. The potential inhibitory activity of pomegranate peel extract polyphenols against virus for effective viral disease therapy has attracted a great deal of scientific interest. The aim of this review was to present an overview of the pomegranate peel effects on viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Influenza virus, Norovirus, Adenovirus, Herpes simplex virus, Coronavirus disease (COVID-19). Pomegranate is consumed as fresh fruit and juice for its reported health benefits as antioxidant, antidiabetic, hypolipidemic, antibacterial, anti-inflammatory, antiviral, anticarcinogenic activities, and improves cardiovascular as well as oral health. The health benefits of pomegranate have been attributed to its wide range of phytochemicals, which are predominantly polyphenols, ellagitannins, anthocyanins, and other polyphenols. Instead of the pomegranate peel being a neglected product, it is considered as a promising antiviral agent which also offers other health benefits without side effects.